ROBO3 (NM_022370) Human 3' UTR Clone

Specifications

Product Data
Product Name	ROBO3 (NM_022370) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	HGPPS; HGPPS1; HGPS; RBIG1; RIG1
ACCN	NM_022370
Insert Size	251 bp
Sequence Data	Insert Sequence (showhide) >SC202642 3’UTR clone of NM_022370 The sequence shown below is from the reference sequence of NM_022370. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGACAGAAACGCCGAGAGGAACCAAGATGACCCTTGTTGGGGCATTGAGAATATCATGAGTGCCACGGG GAAGGGGAGTAGGGATGTCTTTTCCCCCCCAGCAGTGATGAGTGGGGCTAGCTGAAGCCCATTGGTTTC CACGATTTCAATTGGCTGAGAAGGCAGAGAGCTAGCTCCTCCCTTTCTTTCTTTTTCCACCTGAGACTT GTTTATAAAAAACAAAACAATAAAAAGAGTCTGATCAGAGCCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_022370.4
Synonyms	HGPPS; HGPPS1; HGPS; RBIG1; RIG1
Summary	This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. [provided by RefSeq, May 2019]
Locus ID	64221
MW	9.8

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