PML Protein (PML) (NM_002675) Human 3' UTR Clone

Specifications

Product Data
Product Name	PML Protein (PML) (NM_002675) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	MYL; PP8675; RNF71; TRIM19
ACCN	NM_002675
Insert Size	188 bp
Sequence Data	Insert Sequence (showhide) >SC202440 3’UTR clone of NM_002675 The sequence shown below is from the reference sequence of NM_002675. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TGGGGCTACCCCCACCCCTTTCTAATTTAGTCTCTGAGTCCCAAAAAGAAGTGCAGGCAGAGCCATCTG CCAGGCCCAGGAGAGCTCTGAGCTCTGGCCAACAACTGCAGCCAGGCTGGGCAGAGCACTCCGGCTCAC CTGGGCTCCTGGCGTGTCATTTGCTGGCTTGAATAAAGATGTCCGCCTTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002675.4
Synonyms	MYL; PP8675; RNF71; TRIM19
Summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Locus ID	5371
MW	6.9

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