LYAR (NM_001145725) Human 3' UTR Clone
CAT#: SC202297
3' UTR clone of Ly1 antibody reactive homolog (mouse) (LYAR) transcript variant 2 for miRNA target validation
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CNY 4,845.00
货期*
3周
规格
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Specifications
Product Data | |
Product Name | LYAR (NM_001145725) Human 3' UTR Clone |
Vector | pMirTarget |
Synonyms | ZC2HC2; ZLYAR |
ACCN | NM_001145725 |
Insert Size | 219 bp |
Sequence Data |
>SC202297 3' UTR clone of NM_001145725
The sequence shown below is from the reference sequence of NM_001145725. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC GTTATTAAAGGACAAAGTCAAGCTTGTGAAATGAACATTTGTGTATTTAAAAATTGAATCCATTCTGCTG ACTTCTTCCTTTCACTGCTGTTTATAAAATGTGTAATGAATTCTAACAACTCAAATTTTGCTTTTTGAAG CTGTATTTTTAAGTTAAGAAAATATATTTTTGGTATAACTTTTATGAGAAAAATAAAATATATTCTGGTC CAAACTTCT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_001145725.1 |
Synonyms | ZC2HC2; ZLYAR |
Summary | Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).[UniProtKB/Swiss-Prot Function] |
Locus ID | 55646 |
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