FBXO11 (NM_012167) Human 3' UTR Clone

Specifications

Product Data
Product Name	FBXO11 (NM_012167) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	F-box only protein 11; F-box protein 11; FBX11; FLJ12673; MGC44383; PRMT9; ubiquitin protein ligase E3 component n-recognin 6; UBR6; UG063H01; VIT1; vitiligo-associated protein VIT-1
ACCN	NM_012167
Insert Size	219 bp
Sequence Data	Insert Sequence (showhide) >SC202053 3’UTR clone of NM_012167 The sequence shown below is from the reference sequence of NM_012167. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CATATGTATTCAGGGGTTCAGATAAGGTAAATGTTTTCATATTTGGCTATCTTTTGGGAGGGAGTTAGG AGTATGTGGGGTGTGTAAAAGAAATTTGCTTATTGTTTAATGCCCAATCTTTATCCCCCTATTGTATAT ATATTCACATTCTTAAAATAATCTTGACTTAAATTGTCAGAATGTAGCTTTCCTTGGTCTAGGTGAGGA CAGAAGCCACTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_012167.1
Synonyms	F-box only protein 11; F-box protein 11; FBX11; FLJ12673; MGC44383; PRMT9; ubiquitin protein ligase E3 component n-recognin 6; UBR6; UG063H01; VIT1; vitiligo-associated protein VIT-1
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Locus ID	80204
MW	8.7

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