PYGL (NM_002863) Human 3' UTR Clone

Specifications

Product Data
Product Name	PYGL (NM_002863) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	GSD6
ACCN	NM_002863
Insert Size	205 bp
Sequence Data	Insert Sequence (showhide) >SC202026 3’UTR clone of NM_002863 The sequence shown below is from the reference sequence of NM_002863. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AATGAATCTAACAAAGTCAATGGAAATTGAACTCTAGAATTGTCTCTAGAAAACATAGCTTCTTACTGA ACTTGAACATTTTTACAACATTCACTGGTTTTTGTTTTGTTAGCTAATAATCTATAATAGTTGAGTATC TCTGGGAATGGGGAGGGAAATTATATGTAATAGAGCTTAAAAATAAAGTGTCAATTTCCAAGGGCTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002863.5
Synonyms	GSD6
Summary	This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]
Locus ID	5836
MW	7.5

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