IL4R (NM_001008699) Human 3' UTR Clone

Specifications

Product Data
Product Name	IL4R (NM_001008699) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD124; IL4RA
ACCN	NM_001008699
Insert Size	198 bp
Sequence Data	Insert Sequence (showhide) >SC201898 3' UTR clone of NM_001008699 The sequence shown below is from the reference sequence of NM_001008699. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC AGCACCAAGTGGCACAACTCAAATATTTGCTGAGTTCCTCCTACATGGCTAGCCCTGTGCTAGACACTGG GGAATCGGCGATGAACAAAGCAGATAGAAATCCCCACTCTTGTGGAGCTGACATTCTGGAGGGAGAGACA AAAAGCAAACATATAAAGAAAGAAAGAAATCACATGGATCTGGATGACAGTGAGTGCT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001008699.1
Synonyms	CD124; IL4RA
Summary	This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Locus ID	3566

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