PMS2 (NM_000535) Human 3' UTR Clone

Specifications

Product Data
Product Name	PMS2 (NM_000535) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	HNPCC4; MLH4; MMRCS4; PMS2CL; PMSL2
ACCN	NM_000535
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC201825 3’UTR clone of NM_000535 The sequence shown below is from the reference sequence of NM_000535. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCCAACCTGGGTGTCATTTCTCAGAACTGACCGTAGTCACTGTATGGAATAATTGGTTTTATCGCAGAT TTTTATGTTTTGAAAGACAGAGTCTTCACTAACCTTTTTTGTTTTAAAATGAACCTGCTACTTAAAAAA AATACACATCACACCCATTTAAAAGTGATCTTGAGAACCTTTTCAAACCAGATGGAGCATTGCTTGCAA ATTTTTTTTCTCTATGTTTGCATGCGCTCGTGTGTGTGTGTCCAGGCAAGAACACATTTTATAAAAATA AGAACACTTGGGCTGGGCATGGTGGCTCATGCCTGTGATCGCAGCACTTTGGGAGGCCGAGGCCGGCGG ATCACCTGAGATCAGAAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCTGCCTCTACTAAAAATAC AAAATTAGCCAGGTGTGCTGGCGCATGCCTGTAATCCCCGCTACCCAGGAGGCTGAGGCAGGAGAATCG CTTGAACCCGGGAGACGGAGGTTGCAGTGAACCGAGATTGCGCCACTGCGCTCCAGCCTGGGTGAGATA GAACAAGACTGTGTCTCAAAAAACAAAACAAAACAAAACAAAAAAAAAAAAACCAAACCACTTTGGAAG TTACTCAGGCCTCTGCTCTGGCTGGACATAGTTTAGTCTATAACTTTCAACCCTTAATGATAATTAAAT TCATCTTTGTTTAATTTCATAAATTTAAAAGTAGGGTCCTTTTCAGTTAGTGATTCTCAGCCCTGATTC ACATTAAATTTTTAAACACGGGGGATTCTCTGCCCGGCTGGAAGAAAATGACTGGATGGGACAGGGGTC ACTATTTGAAACATTCCTCTGTGCGGCCAAGGTCGCAAAATGCTGTCCTCGCAGGGGAACAAAAAGAGT TTGATTTCCCATAATTTGATGCTGTGATTTGGTTTCCTCAGGATGTGAACTGTAGAACATTCCAGTTAC TGGCCTTGAATGGTTCTGGGAATATAAGAATCCCTGTCTGTCTTTTCAAATAGTTTTCATGGAACCTTG TCCTGTTTGAACTTGGCTGAAAATGGAAGTAAAGATGCCCTCTTGGGGGCCCAGAGATGACAGATGTGG CTCCCCCTGCTGCCCCCACCCCTTCTCCAGACTGTGGGCGGCTCCCCTTCCTGCTTTAGAATCCCTCAG ATGGAGGAGGCAGTACAGTAGTCACTGTGCCATCGTGTCTGGCACTGTGCTGGCGTGGTCTGCAGGATC CCACTTATGAACTCTCCAGATTGGGAGCTGTGGCAGGATAACAGCCCCCAAGACAGCTGTGTCCTAATC CCCAGAACCTGTGACCACGCTGCCTCACGTGGCAGAAGGGACTCGGCAGGTGTGATTGAGTGAAGGATC TTTTTTTTTTTTTTCTTTGAGATGAAGTTTCGCTCTTGTTGCCCAGGCTGGAGTTCAATAGCATGATCT CAGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGTGATTCTCCCACCTCAGCCTCCCGAGTAGCTGGGA TTACAGGTGTCCAGAACCATACTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGA CCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGACCGCCTCGGCCTCCCAAAGTGCTGGGATTAC AGGTGTGAGCCATCATGCCTGGCTGAGTTAAGGATCTTGCAACAGAGAGATTATCCTGGATTGTCTGGG TGGGCCCAGTCCATTGGGTGAGTCCTTCAAAGGTGGAGACCTTTCCCTGCTGGCCAGAGAGAGGCTGTC TTGCTGGTTTTGGAGATGGAAGGAGGTACCACTAGTCAAGGATTGCAAGCAGTCTCTAGAACAGGGATT CCAACACTCCGGACACAGACCAGTAGTGGTCCATGGCCTATTAGGAAGTGGGGTGCACAGCAGGTTAGG GGCCGGCAAGCCAGCGAAGCTTCATCTGTATTTATAGCCACTCCCCGTCGCTGGCGTTACCACCCGAG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000535.7
Synonyms	HNPCC4; MLH4; MMRCS4; PMS2CL; PMSL2
Summary	The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]
Locus ID	5395
MW	75.2

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