PSTPIP1 (NM_003978) Human 3' UTR Clone

Specifications

Product Data
Product Name	PSTPIP1 (NM_003978) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP
ACCN	NM_003978
Insert Size	329 bp
Sequence Data	Insert Sequence (showhide) >SC201724 3’UTR clone of NM_003978 The sequence shown below is from the reference sequence of NM_003978. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTCCCTGGTTCCTACCTGGAGAAGCTTTGAGGAAGGGCCAGGAGCCCCTTCGGACCTGCCCTGCCAGTG GAGCCAGCAGTGCCCCCAGCACTGTCCCCACCTTGCTAGGGCCCAGAACCAAGCGTCCCCCAGCCCCGA GAGGGAGCCTGTCGTCTCCCAGGGAATAAAGGAGTGCGTTCTGTTCTCCTTGGTGTGCTGGGGTCCCGT TCTCTTTTTCTCCTGCTCCAGTGTCCGAGTGCTCAGTTCAGAGGAGGCAAAGGAACAAGGGAAGGAGCC TGGATGTGGAGCTCCCCAACTCAGCCGAGGCTTCAGCTATAGTTGGAGAAGAG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003978.5
Synonyms	CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP
Summary	This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]
Locus ID	9051
MW	11.6

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