PSMA (FOLH1) (NM_004476) Human 3' UTR Clone

Specifications

Product Data
Product Name	PSMA (FOLH1) (NM_004476) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA
ACCN	NM_004476
Insert Size	1694 bp
Sequence Data	Insert Sequence (showhide) >SC201229 3’UTR clone of NM_004476 The sequence shown below is from the reference sequence of NM_004476. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCTGCAGAGACTTTGAGTGAAGTAGCCTAAGAGGATTCTTTAGAGAATCCGTATTGAATTTGTGTGGTA TGTCACTCAGAAAGAATCGTAATGGGTATATTGATAAATTTTAAAATTGGTATATTTGAAATAAAGTTG AATATTATATATAGTTATGTGAGTGTTTATATATGTGTGTGTTTATATTGTTTATCTTCTCCCTATGGA TTAAAACTGAATTTCATAATTATAAGAGGTTATTCTGAAGTGGAAAAATTTAACTCAGTATTAAATCTA AGGAGAATGGCCTAATATAGTAAAACTCTCATCTGGCATTATCAGGGAATCAAGTCTAATCTATTCATG TCACTTCACACAGAAGAAAACATCAGTATGTCAGAGAGCACACTGGGGAATATGCACAAGATTATCCCA AGCCAGAGGCCTCACGGCCTACCTGGCCAGCCTGGGCTGAGAGGATCACTATCTCAGCACACTATTTGG GAAATGGATCAAATCACACTTTTAGTAAATGTTATCACTCTATAGCATAAGAAATAATTATTTTTTATT TATATAAAAGGCTATAGTATAAAATATATGTATAGTAATTAAATGAACACTTGTGAACCTAATAGCCAT ATGAAGAAAATAACATTTCTAATATCTTTGGATGCCCCATGTACTAATGACAGTTATGCTTTTGCATTT TCTTGAATTTTATGTTTATTTATCTTTCCTCTGTCATTATTTATAATTTTATCACACATGGCTGTATCC TTTACATGTTTTGGCATTATGTATTTTTGAACTTTTTGTAAAGACAATCATACCATGTGTAATTTTCAG GGACTTGATTTTTTTCATTGACTTTTAAGGGTTCAAATATATTATCACTGTGGCTGTAGTTTGCCATAT TTTGCTGATATAGAGCATTCATTCACATGAGGGTAGGATTCAGGGTCCATCAAGACAGAGAAAACATAC AGTAATGTGAATAGGGAAAGTTAATATGAAGAATTATTAATTGTTACAGCATTGGAACAATGAAATATT GTCTAGTAATATGTAAAGAGAAGTCTCAAGAATATGTGATGAGCAGATGTAAGGAATTGCTCTTGTCTC CATGGTGAATTTGGAGCAGCCAATGAAGAGTCCCCTCACATTGTGGCCTCGCTCAAAGTTAAGAAGTCG CTGTAGTGTTGCCCTTGAAGAATCTGCTTCAAATTGACACTTCAGAACTCCCCAGAAACTTGTCTTCTG GGCCAATGTGTAAAGCTGTTTATGAAGAAATGTCAAGCCAGAGGGGCTCTACTACAAATTTGGCAAAGG ACAATTTCAGGAGAAGCTCTTGGCCGCTGGGTTCTCCTGGCCACCATGAACTTCAGGAAGTGGGTGCCA TAGCAGCAGCCTGAACTACAGAATCTGGGCACTGGTGTAGCTCTGTATGCCCTCCGTGTCAGATGCTGG AGATGTCATTTGCATTGCCAGAGTTTGCCAAGGGTGCACACAGAAAGCAGATTGAAAAGCACCCTCTTG GAACATCTCTCCAATGCCTTCTACTCACAAAGTTTAACATCATTAACACGTGACAAAGAAGAACTATTT AATGGGCCCAGATCTATTTATGAAGACAATCAAGTGGGAGTTTGGAGTGGATAACCCAAATTTGGATAA CTGGTGAATAATAAAATGTATTTATTTCTGCTGGTGTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004476.3
Synonyms	FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA
Summary	This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Locus ID	2346
MW	64.7

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