Troponin I fast skeletal muscle (TNNI2) (NM_003282) Human 3' UTR Clone

Specifications

Product Data
Product Name	Troponin I fast skeletal muscle (TNNI2) (NM_003282) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AMCD2B; DA2B; DA2B1; FSSV; fsTnI
ACCN	NM_003282
Insert Size	157 bp
Sequence Data	Insert Sequence (showhide) >SC201176 3’UTR clone of NM_003282 The sequence shown below is from the reference sequence of NM_003282. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CGGAAGAAGATGTTTGAGTCCGAGTCCTAGGCCACTCGCTGCCCCTACGCCTGCCCCGGTGCCCGGCTC CCAGCAGAACATACTAGGGAGATGCACCCAGAGCCTGCCAGGGAGGGCTGGCCTCACCACCACCGTCAA TAAAGGATTTGAATCCCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003282.4
Synonyms	AMCD2B; DA2B; DA2B1; FSSV; fsTnI
Summary	This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Locus ID	7136
MW	6.1

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