Neutrophil Elastase (ELANE) (NM_001972) Human 3' UTR Clone

Specifications

Product Data
Product Name	Neutrophil Elastase (ELANE) (NM_001972) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ELA2; GE; HLE; HNE; NE; PMN-E; SCN1
ACCN	NM_001972
Insert Size	109 bp
Sequence Data	Insert Sequence (showhide) >SC200560 3’UTR clone of NM_001972 The sequence shown below is from the reference sequence of NM_001972. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GACCCGGACCCGGCCAGCAGGACCCACTGAGAAGGGCTGCCCGGGTCACCTCAGCTGCCCACACCCACA CTCTCCAGCATCTGGCACAATAAACATTCTCTGTTTTGTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001972.4
Synonyms	ELA2; GE; HLE; HNE; NE; PMN-E; SCN1
Summary	Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]
Locus ID	1991
MW	3.9

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