Human REG1 alpha (REG1A) ELISA KIT (1 x 96 wells)

Specifications

Product Data
Description	Human REG1 alpha (REG1A) ELISA KIT (1 x 96 wells)
Size	1 x 96 wells
Format	8x12 divisible strips
Assay Type	Sandwich
Assay Length	3.5 hours incubations; 1 hour washing and analyzing samples
Signal	Colorimetric
Curve Range	15.6pg/ml-1000pg/ml
Sample Type	Human serum, plasma and other biological fluids.
Sample Volume	100µl
Specificity	This kit is used for quantitative detection of Human PSP/REG1A
Sensitivity	5.3pg/ml
Reactivity	Human
Cross Reactivity	There is no detectable cross-reactivity with other relevant proteins.
Interference	No significant interference observed with available related molecules.
Components	PSP/REG1A Antibody Coated 96-well Plate in foil pouch with desiccant|1 plate Recombinant Human PSP/REG1A Standard (50ng/ml)|0.1 mL 100x Biotinylated Human PSP/REG1A Detection Antibody|0.12 mL 100x Peroxidase Conjugate|0.12 mL Assay Buffer|30 mL Sample Diluent|15 mL Wash Buffer Concentrate 20X|60 mL TMB Substrate|12 mL Stop Solution|12 mL
Background	Pancreatic stone protein (PSP), also known as lithostathine, and regenerating protein (REG1A). It is a secreted, type I subclass member of the regenerating protein family. Mature human PSP/REG1A shares 76% and 69% aa sequence identity with mouse and rat PSP/REG1A, respectively. PSP/REG1A is constitutively expressed by pancreatic acinar cells, and is also induced in proliferating cell types such as colonic epithelium, islet beta-cells, and multiple tumor types. The 16 kDa precursor of PSP/REG1A has been observed mainly in the pancreas and is transiently elevated in acute and chronic pancreatitis. PSP/REG1A has been found both in blood and pancreatic secretions. PSP/REG1A plays a role in blocking apoptosis, and is upregulated by both IL-22 and IL-6. Under healthy conditions PSP/REG1A is expressed at low levels in the pancreas. Upon focal or systemic inflammation, PSP/REG1A is strongly increased. PSP/REG1A is elevated in various conditions such as sepsis, ventilator associated pneumonia (VAP), chronic obstructive pulmonary disease (COPD) exacerbation, and type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). These observations indicated that PSP/REG1A might respond to infectious conditions and organ failure. The use of the PSP/REG1A as a biomarker has been confirmed the high diagnostic accuracy for sepsis. In addition, evidences obtained regarding PSP/REG1A and its isoforms on regeneration, growth and mitogenesis in gastrointestinal neoplastic diseases suggest that PSP/REG1A can be used as biomarker in the prediction of prognosis for neoplastic diseases.
Gene Symbol	REG1A
Standard Curve	Data image for REG1 alpha (REG1A) ELISA Kit.

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