Human alpha 1 Antitrypsin (SERPINA1) ELISA KIT (1 x 96 wells)

Specifications

Product Data
Description	For quantitative detection of human Serpin A1 in cell culture supernates, serum, plasma (heparin, EDTA) and urine.
Size	1 x 96 wells
Format	8x12 divisible strips
Assay Type	Sandwich ELISA kit of Quantitative Detection for Human Serpin A1
Assay Length	3.5 hours incubations; 1 hour washing and analyzing samples
Signal	Colorimetric
Curve Range	1.56 ng/ml-100 ng/ml
Specificity	This kit is used for quantitative detection of Human Serpin A1
Sensitivity	<10 pg/ml
Reactivity	Human
Cross Reactivity	There is no detectable cross-reactivity with other relevant proteins.
Components	96-well plate precoated with anti- Human Serpin A1 antibody | 1 Lyophilized recombinant Human Serpin A1 standard | 100ng/tubex2 Biotinylated anti- Human Serpin A1 antibody | 100ul(dilution 1:100) Avidin-Biotin-Peroxidase Complex(ABC) | 100ul(dilution 1:100) Sample diluent buffer | 30ml Antibody diluent buffer | 12ml ABC diluent buffer | 12ml TMB color developing agent | 10ml TMB stop solution | 10ml Wash Buffer (25x) | 20ml Adhesive cover | 4
Background	Alpha-1-antitrypsin or α1-antitrypsin (A1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1 gene. The gene is located on the long arm of the fourteenth chromosome (14q32.1).The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Mutations in these areas can lead to non-functional proteins that can polymerise and accumulate in the liver(infantile hepatic cirrhosis).
Gene Symbol	SERPINA1

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