Human Perforin ELISpot Pair, 10 x 96-well

Specifications

Product Data
Description	Human Perforin ELISpot Pair, 10 x 96-well
Size	10 x 96 wells
Format	10 x 96-well
Assay Type	Enzyme-Linked ImmunoSpot (ELISpot)
Signal	Colorimetric
Specificity	Recognizes natural human Perforin
Cross Reactivity	No cross reactivity with other human soluble molecules
Components	ELISpot matched antibody pairs are extensively validated and include pre-titrated capture antibody and biotinylated detection antibody. Antibodies are supplied in quantities sufficient for 10 x 96 samples.
Background	The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Symbol	PRF1

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