Human IL-12p40 ELISA Set, 5 x 96-well

Specifications

Product Data
Description	Human IL-12p40 ELISA Set, 5 x 96-well
Size	5 x 96 wells
Format	5 x 96-well
Assay Type	Solid Phase Sandwich ELISA
Assay Length	From sample to end 3h45min
Signal	Colorimetric
Curve Range	62.5-2000 pg/ml
Sample Type	Serum, Plasma, Cell culture supernatant, buffered solution
Sample Volume	100 µl
Specificity	Recognizes the p40 monomer, dimer or heterodimer (p40+p35) forms of the molecule
Sensitivity	20 pg/ml
Cross Reactivity	No cross reactivity with other human cytokines
Components	ELISA Sets include capture and biotinylated detection antibody, one standard per plate, Streptavidin-HRP, TMB, and detailed procedure including buffer composition.
Background	This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
Gene Symbol	IL12B

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