Human CD124 ELISA Kit, 2 x 96-well (pre-coated)

Specifications

Product Data
Description	Human CD124 ELISA Kit, 2 x 96-well (pre-coated)
Size	2 x 96 wells (pre-coated)
Format	2 x 96-well (pre-coated)
Assay Type	Solid Phase Sandwich ELISA
Assay Length	1h45min
Signal	Colorimetric
Curve Range	31.25-1000 pg/ml
Sample Type	Serum, Plasma, Cell culture supernatant
Sample Volume	100 µl
Specificity	Recognizes both natural and recombinant human soluble IL-4R
Sensitivity	11.5 pg/ml
Cross Reactivity	No cross reactivity with other human soluble receptors
Interference	No significant interference observed with available related molecules.
Components	ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents, and a detailed procedure.
Background	This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Gene Symbol	IL4R
Standard Curve	Representative Standard Curve

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