Mouse Osteoactivin/GPNMB ELISA Kit
CNY 5,000.00
货期*
3周
规格
Cited in 1 publication. |
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Specifications
Product Data | |
Description | Mouse Osteoactivin/GPNMB ELISA Kit |
Size | 1 x 96 wells |
Assay Type | Sandwich ELISA kit of Quantitative Detection for Mouse Osteoactivin/GPNMB |
Assay Length | 3.5 hours incubations; 1 hour washing and analyzing samples |
Signal | Colorimetric |
Curve Range | 156pg/ml-10,000pg/ml |
Sample Type | Cell culture supernates, serum and plasma(heparin, EDTA). |
Sample Volume | 100 ul |
Specificity | This kit is used for quantitative detection of mouse Osteoactivin |
Sensitivity | <10pg/ml |
Reactivity | Mouse |
Cross Reactivity | There is no detectable cross-reactivity with other relevant proteins. |
Interference | No significant interference observed with available related molecules. |
Components |
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Background | Transmembrane glycoprotein NMB is a protein that is encoded by the GPNMB gene. In osteoblast progenitor cells, GPNMB works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. GPNMB can enhance the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis(soft callus) and osteogenesis(hard callus) compared to the intact femurs that is why Osteoactivin(OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, GPNMB expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells. |
Gene Symbol | Gpnmb |
Citations (1)
The use of this Assay Kits has been cited in the following citations: |
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Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice
,Wu, JW;Preuss, C;Wang, SP;Yang, H;Ji, B;Carter, GW;Gladdy, R;Andelfinger, G;Mitchell, GA;,
PLoS Genet.
,PubMed ID 28459858
[GPNMB]
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