TNFRSF4 Mouse Monoclonal Antibody [Clone ID: UMAB276]

Specifications

Product Data
Clone Name	UMAB276
Applications	10k-ChIP, FC, IHC, WB
Recommend Dilution	IHC 1:100~300
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human TNFRSF4 (NP_003318) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	29.34 kDa
Gene Name	TNF receptor superfamily member 4
Database Link	NP_003318 Entrez Gene 7293 Human UniProt ID P43489
Background	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Synonyms	ACT35; CD134; IMD16; OX40; TXGP1L
Reference Data
Protein Families	Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction

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