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P Glycoprotein (ABCB1) Mouse Monoclonal Antibody [Clone ID: OTI1B8]
CAT＃: TA814176
MDR-1/ABCB1 mouse monoclonal antibody, clone OTI1B8
Size: 30 ul
Formulation: Carrier Free
View other "OTI1B8" antibodies (4)
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CNY 1,999.00
CNY 3,600.00
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CNY 300.00
CNY 1,430.00
Specifications
| Product Data | |
| Clone Name | OTI1B8 |
| Applications | IHC |
| Recommend Dilution | IHC 1:200 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human MDR-1/ABCB1 (NP_000918) produced in E.coli. |
| Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage Condition | Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws. |
| Predicted Protein Size | 141.3 kDa |
| Gene Name | ATP binding cassette subfamily B member 1 |
| Database Link | |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017] |
| Synonyms | ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1 |
| Reference Data | |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | ABC transporters |
Documents
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| CF814176 | Carrier-free (BSA/glycerol-free) MDR-1/ABCB1 mouse monoclonal antibody, clone OTI1B8 |
CNY 3,999.00 |
|
| TA814176AM | MDR-1/ABCB1 mouse monoclonal antibody, clone OTI1B8, Biotinylated |
CNY 3,990.00 |
|
| TA814176BM | MDR-1/ABCB1 mouse monoclonal antibody, clone OTI1B8, HRP conjugated |
CNY 3,990.00 |
|
| TA814176S | MDR-1/ABCB1 mouse monoclonal antibody, clone OTI1B8 |
CNY 800.00 |
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