DIP13B (APPL2) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI6G8]
CAT#: TA812390AM
APPL2 mouse monoclonal antibody,clone OTI6G8, Biotinylated
Conjugation: Unconjugated HRP
View other "OTI6G8" antibodies (4)
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CNY 3,990.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 3,080.00
Specifications
Product Data | |
Clone Name | OTI6G8 |
Applications | WB |
Recommend Dilution | WB 1:2000 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human APPL2 (NP_060641) produced in HEK293T cell. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Biotin |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 74.3 kDa |
Gene Name | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 |
Database Link | |
Background | The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011] |
Synonyms | DIP13B |
Reference Data |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF812390 | Carrier-free (BSA/glycerol-free) APPL2 mouse monoclonal antibody,clone OTI6G8 |
CNY 3,999.00 |
|
TA812390 | APPL2 mouse monoclonal antibody,clone OTI6G8 |
CNY 1,999.00 |
|
TA812390BM | APPL2 mouse monoclonal antibody,clone OTI6G8, HRP conjugated |
CNY 3,990.00 |
|
TA812390S | APPL2 mouse monoclonal antibody,clone OTI6G8 |
CNY 800.00 |