PON3 Mouse Monoclonal Antibody [Clone ID: OTI1F12]

Specifications

Product Data
Clone Name	OTI1F12
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 30-319 of human PON3(NP_000931) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	39.4 kDa
Gene Name	paraoxonase 3
Database Link	NP_000931 Entrez Gene 5446 Human UniProt ID Q15166
Background	This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Synonyms	lactonase 3; paraoxanase-3; paraoxonase 3; serum paraoxonase
Reference Data
Protein Families	Secreted Protein, Transmembrane
Protein Pathways	Metabolic pathways

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