Renin (REN) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1D3]

Specifications

Product Data
Clone Name	OTI1D3
Applications	IHC, WB
Recommend Dilution	WB 1:500, IHC 1:150
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 131-406 of human REN(NP_000528) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	42.3 kDa
Gene Name	renin
Database Link	NP_000528 Entrez Gene 5972 Human UniProt ID P00797
Background	Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
Synonyms	ADTKD4; HNFJ2; RTD
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Renin-angiotensin system

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