Chk1 (CHEK1) Rabbit Monoclonal Antibody [Clone ID: OTIR3G7]
CAT#: TA591044
Rabbit monoclonal anti-CHK1 antibody for SISCAPA, clone OTIR3G7
Need it in bulk or conjugated?
Get a free quote
CNY 4,390.00
Cited in 1 publication. |
Product images
CNY 3,080.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
Specifications
Product Data | |
Clone Name | OTIR3G7 |
Applications | SISCAPA |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human CHEK1 (NP_001265). The exact sequence is proprietary. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | Lot dependent; please refer to CoA along with shipment |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 54.4 kDa |
Gene Name | checkpoint kinase 1 |
Database Link | |
Background | The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011] |
Synonyms | CHK1 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase, Stem cell - Pluripotency |
Protein Pathways | Cell cycle, p53 signaling pathway |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
---|
GDC-0575, a CHK1 Inhibitor, Impairs the Development of Colitis and Colitis-Associated Cancer by Inhibiting CCR2+ Macrophage Infiltration in Mice
,null,
OncoTargets and therapy
,PubMed ID 33897258
[Chk1]
|
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |