CD95 (FAS) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1F2]

CAT#: TA506903AM

FAS mouse monoclonal antibody,clone 1F2, Biotinylated

Conjugation: Unconjugated Biotin HRP



  View other "OTI1F2" antibodies (4)

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CNY 3,990.00


货期*
2周

规格
    • 100 ul

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经常一起买 (3)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Recombinant protein of human Fas (TNF receptor superfamily, member 6) (FAS), transcript variant 1, 20 µg
    • 20 ug

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Transient overexpression lysate of Fas (TNF receptor superfamily, member 6) (FAS), transcript variant 2
    • 100 ug

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Specifications

Product Data
Clone Name OTI1F2
Applications WB
Recommend Dilution WB 1:2000
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human FAS(NP_000034) produced in HEK293T cell.
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Biotin
Storage Condition Store at -20°C as received.
Predicted Protein Size 36 kDa
Gene Name Fas cell surface death receptor
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Synonyms ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Allograft rejection, Alzheimer's disease, Apoptosis, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Pathways in cancer, Type I diabetes mellitus
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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