MVK Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI 1D7]

Specifications

Product Data
Clone Name	OTI 1D7
Applications	IF, WB
Recommend Dilution	WB 1:2000, IF 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human MVK (NP_000422) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	42.3 kDa
Gene Name	mevalonate kinase
Database Link	NP_000422 Entrez Gene 4598 Human UniProt ID Q03426
Background	This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Two transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms	LRBP; MK; MVLK; POROK3
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Terpenoid backbone biosynthesis

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