Cytokeratin 8 (KRT8) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1B12]

Specifications

Product Data
Clone Name	OTI1B12
Applications	IF, IHC, WB
Recommend Dilution	WB 1:2500~5000, IHC 1:50 - 1:150, IF 1:50 - 1:100
Reactivity	Human, Dog, Rat, Monkey, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 91-381 of human CK8 (NP_002264) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	53.5 kDa
Gene Name	keratin 8
Database Link	NP_002264 Entrez Gene 16691 MouseEntrez Gene 25626 RatEntrez Gene 486513 DogEntrez Gene 3856 Human UniProt ID P05787
Background	Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
Synonyms	CARD2; CK-8; CK8; CYK8; K2C8; K8; KO
Reference Data
Protein Families	Druggable Genome

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