Trem1 Rat Monoclonal Antibody [Clone ID: L5-B8.2A12.3A12]

Specifications

Product Data
Clone Name	L5-B8.2A12.3A12
Applications	FC, IF, IHC, WB
Host	Rat
Clonality	Monoclonal
Immunogen	Mouse TREM-1 Fc fusion protein.
Specificity	TREM-1
Formulation	Phosphate buffered saline containing 0.09%Sodium Azide (NaN3) Label: ALEXA FLUOR® 488,ALEXA FLUOR® 647,FITC,Low Endotoxin,Purified,RPE State: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant Purified IgG - liquid
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	+4°C, -20°C if preferred
Gene Name	triggering receptor expressed on myeloid cells 1
Database Link	UniProt ID Q9JKE2
Background	Rat anti Mouse Trem-1 antibody, clone L5-B8.2A12.3A12 recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1. TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection.
Synonyms	TREM-1
Reference Data

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