Phospho-IRF3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB,1:2000 - 1:24000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic phosphorylated peptide around S396 of human IRF3 (NP_001562.1).
Formulation	Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	47kDa - Observed MW: 45-55kDa
Gene Name	interferon regulatory factor 3
Database Link	Entrez Gene 3661 Human UniProt ID Q14653
Background	This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7.
Synonyms	IIAE7
Reference Data

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