Phospho-beta Catenin (CTNNB1) Rabbit Polyclonal Antibody
CNY 7,740.00
货期*
5周
规格
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB,1:500 - 1:1000 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic phosphorylated peptide around S552 of human Phospho-β-Catenin-S552 (NP_001895.1). |
Formulation | Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 85kDa - Observed MW: 92kDa |
Gene Name | catenin beta 1 |
Database Link | |
Background | The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. |
Synonyms | armadillo; CTNNB; EVR7; MRD19; NEDSDV |
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