FCGRT Rabbit Monoclonal Antibody [Clone ID: h22-0015]

Specifications

Product Data
Clone Name	h22-0015
Applications	Bl
Reactivity	Human
Modifications	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Host	Rabbit
Clonality	Monoclonal
Immunogen	The original antibody was generated by immunizing Balb/c mice with recombinant FcRn.
Specificity	The antibody is specific for human FcRn. The neonatal Fc receptor is a cell surface receptor that transfers passive humoral immunity from the mother to the newborn. The antibody was employed in blocking experiments with HEK293 cells that overexpress FcRn. The results showed that the antibody has a good effect of blocking the binding of IgG to FcRn at the cellular level (IC50: 11.4nM). The effect of the antibody was tested in human FcRn transgenic mice. The antibody was able to increase IgG catabolism in vivo by blocking FcRn binding (CN113484526).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Database Link	UniProt ID P55899
Synonyms	FCGRT; IgG Fc fragment receptor transporter alpha chain; IgG receptor FcRn large subunit p51; Neonatal Fc receptor
Reference Data

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