Casein Kinase 1 alpha (CSNK1A1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human Casein Kinase Iα around the phosphorylation site of Tyrosine 321
Specificity	p-Casein Kinase Iα (Y321) pAb detects endogenous levels of Casein Kinase Iα protein only when phosphorylated at Tyr321.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 34 kDa
Gene Name	casein kinase 1 alpha 1
Database Link	Entrez Gene 1452 Human UniProt ID P48729
Background	Casein kinase I (also designated CKI) and casein kinase II (also designated CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. CKI family members, which include CKIα, β, γ, e and δ, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an α2β2 or an αα'β2 structure. The a catalytic subunit is stimulated by the β regulatory subunit, which undergoes autophosphorylation. CKII activity is high in the cytosol and nucleus of proliferating and differentiating cells. CKII is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.
Synonyms	Casein kinase I isoform alpha; CK-Iα; CK1; CKI-alpha; CKI-α; CK Iα; CKIα; CSNK1A1
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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