TBC1D4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human TBC1D4 around the phosphorylation site of Threonine 642.
Specificity	p-TBC1D4 (T642) polyclonal antibody detects endogenous levels of TBC1D4 only when phosphorylated at Thr642.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 160 kDa
Gene Name	TBC1 domain family member 4
Database Link	Entrez Gene 9882 Human UniProt ID O60343
Background	TBC1 domain family member 4 (TBC1D4), also designated AS160, can be insulin- and/or AKT1-induced. Insulin-stimulated phosphorylation is required for GLUT4 translocation. TBC1D4 may play a role as a GTPase activating protein for proteins in the Rab family. It is expressed primarily in skeletal muscle and heart, as well as spleen, lymph node and leukocytes. Defects in the TBC1D4 gene may cause atopic dermatitis (AD), sometimes referred to as eczema, an atopic chronic skin disease. The skin of affected individuals reacts to irritants or allergens and becomes red, flaky and itchy. The skin is also more vulnerable to inflammations, and symptoms can grow or disappear over time.
Synonyms	Akt substrate of 160 kDa; AS160; KIAA0603; TBC1 domain family member 4; TBC1D4
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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