14-3-3 zeta (YWHAZ) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human Histone 14-3-3 ζ around the phosphorylation site of Serine 58.
Specificity	p-14-3-3 ζ (S58) polyclonal antibody detects endogenous levels of 14-3-3 protein zeta/delta only when phosphorylated at Ser58.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 28 kDa
Gene Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Database Link	Entrez Gene 7534 Human UniProt ID P63104
Background	14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities.
Synonyms	14-3-3 protein delta; 14-3-3 protein zeta; 14-3-3 protein zeta/delta; 14-3-3 δ; 14-3-3 ζ; 1433Z; KCIP-1; KCIP 1; KCIP1; Protein kinase C inhibitor protein 1; YWHAZ
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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