GPR44 (PTGDR2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 80-127 of Human GPR44.
Specificity	GPR44 (D113) polyclonal antibody detects endogenous levels of GPR44 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 49 kDa
Gene Name	prostaglandin D2 receptor 2
Database Link	Entrez Gene 11251 Human UniProt ID Q9Y5Y4
Background	G protein-coupled receptors (GPCRs), such as GPR44, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response. GPR44 has recently been found to belong to the prostanoid receptor family and named DP2, with this becoming the official IUPHAR nomenclature. GPR44 has recently been found when activated by elevated level of prostaglandin D2 (PGD2), it could inhibit hair growth. This suggests the PGD2-GPR44 pathway as a potential target for bald treatment. A particularly promising compound for blocking the PGD2-GPR44 pathway is a compound known as TM-30089, which exhibits a "functional insurmountability" of PGD2 expression.
Synonyms	CD_antigen=CD294; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH2; DL1R; DP-2; DP2; G-protein coupled receptor 44; GPR44; Prostaglandin D2 receptor 2; PTGDR2
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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