HEXIM1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 191-240 of Human Hexim1.
Specificity	Hexim1 (Q215) polyclonal antibody detects endogenous levels of Hexim1 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 41 kDa
Gene Name	hexamethylene bis-acetamide inducible 1
Database Link	Entrez Gene 10614 Human UniProt ID O94992
Background	Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins which inhibit positive transcription elongation factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit, Cdk9, and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues.
Synonyms	Cardiac lineage protein 1; CLP1; EDG1; Estrogen down-regulated gene 1 protein; Hexamethylene bis-acetamide-inducible protein 1; HEXIM1; HIS1; MAQ1; Menage a quatre protein 1; Protein HEXIM1
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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