FARP2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 341-390 of Human FIR.
Specificity	FIR (P364) polyclonal antibody detects endogenous levels of FIR protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 120 kDa
Gene Name	FERM, ARH/RhoGEF and pleckstrin domain protein 2
Database Link	Entrez Gene 9855 Human UniProt ID O94887
Background	FARP2 (FERM, RhoGEF and pleckstrin domain-containing protein 2), also known as PLEKHC3 or FERM domain including RhoGEF (FIR), is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.
Synonyms	FARP2; FERM, RhoGEF and pleckstrin domain-containing protein 2; FERM domain including RhoGEF; FIR; KIAA0793; PH domain-containing family C member 3; Pleckstrin homology domain-containing family C member 3; PLEKHC3
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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