PI 3 Kinase Class 3 (PIK3C3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human VPS34 around the phosphorylation site of Ser249.
Specificity	VPS34 (phospho-Ser249) polyclonal antibody detects endogenous levels of VPS34 protein only when phosphorylated at Ser249.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 100 kDa
Gene Name	phosphatidylinositol 3-kinase catalytic subunit type 3
Database Link	Entrez Gene 5289 Human UniProt ID Q8NEB9
Background	VPS34 (vacuolar protein sorting-associated protein 34), also known as VPT29, VPL7, PEP15 or END12, is a 875 amino acid peripheral membrane protein that localizes to the golgi apparatus. Belonging to the PI3/PI4-kinase family, VPS34 is involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. The VPS34 PI3-kinase complex II is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes. It has been suggested that VPS34 may also be involved in ethanol tolerance and cell wall integrity.
Synonyms	hVps34; Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC:2.7.1.137); Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; PI3-kinase type 3; PI3K type 3; PIK3C3; PtdIns-3-kinase type 3
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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