SLC16A5 Rabbit Polyclonal Antibody
CAT#: TA392677S
SLC16A5 (A193) polyclonal antibody
Size: 100 ul
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CNY 300.00
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1:500~1:1000 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 161-210 of Human SLC16A5. |
Specificity | SLC16A5 (A193) polyclonal antibody detects endogenous levels of SLC16A5 protein. |
Formulation | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Concentration | 1mg/ml |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Predicted Protein Size | ~ 55 kDa |
Gene Name | solute carrier family 16 member 5 |
Database Link | |
Background | Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT6 is highly expressed in the kidneys and is thought to have a specificity for bumetanide, a loop diuretic involved in the treatment of edema. The high substrate specificity of MCT6 suggests a possible role in therapeutic drug transport and trafficking across the plasma membrane. |
Synonyms | MCT 5; MCT5; MCT 6; MCT6; Monocarboxylate transporter 5; Monocarboxylate transporter 6; SLC16A5; Solute carrier family 16 member 5 |
Note | For research use only, not for use in diagnostic procedure. |
Reference Data |
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