JAK2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB:1:2000~1:5000 IF: 1:50~1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein.
Specificity	JAK2 polyclonal antibody detects endogenous levels of JAK2 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 130 kDa
Gene Name	Janus kinase 2
Database Link	Entrez Gene 3717 Human UniProt ID O60674
Background	JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
Synonyms	JAK-2; JAK2; Janus Activating Kinase 2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK10; kinase Jak2; OTTHUMP00000043260; THCYT3; Tyrosine-protein kinase JAK2; Tyrosine protein kinase JAK2
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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