IKK beta (IKBKB) Rabbit Polyclonal Antibody

CAT#: TA392596S

IKKβ (Y188) polyclonal antibody

Size: 25 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 25 ul

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Specifications

Product Data
Applications IF, WB
Recommend Dilution WB: 1:2000~1:5000 IF: 1:50~1:200
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to Human IKKβ.
Specificity IKKβ (Y188) polyclonal antibody detects endogenous levels of IKKβ protein.
Formulation Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration 1mg/ml
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size ~ 96 kDa
Gene Name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Background The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins. Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB. The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation.
Synonyms I-kappa-B-kinase beta; I-kappa-B kinase 2; IKBKB; IkBKB; IKK-B; IKK-beta; IKK2; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta; Serine/threonine protein kinase IKBKB
Note For research use only, not for use in diagnostic procedure.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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