Estrogen Related Receptor beta (ESRRB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1:1000~1:2000 IF: 1:50~1:200
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human ERRβ.
Specificity	ERRβ polyclonal antibody detects endogenous levels of ERRβ protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 48 kDa
Gene Name	estrogen related receptor beta
Database Link	Entrez Gene 2103 Human UniProt ID O95718
Background	ERRβ/γ Antibody (E-1) is a high quality monoclonal ERRβ/γ antibody (also designated ERRβ/γ antibody) suitable for the detection of the ERRβ/γ protein of mouse, rat and human origin. ERRβ/γ Antibody (E-1) is available as both the non-conjugated anti-ERRβ/γ antibody form, as well as multiple conjugated forms of anti-ERRβ/γ antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Estrogen and progesterone receptors are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. Estrogen receptor-related proteins (ERRα, β and γ) are orphan nuclear receptors. Like estrogen receptors, ERRs bind specifically to EREs to activate reporter genes. ERRβ, also known as steroid hormone receptor ERR2 or estrogen receptor-like 2, is expressed during mammary gland development and is critical in embryo development. The loss of ERRβ results in severely impaired chorion formation leading to placental failure and embryonic death. ERRβ also potently represses the transcriptional activity of Nrf2. ERRγ, also known as ERR3, is abundantly expressed in fetal heart. The loss of ERRγ results in lactatemia and death within the first week of life.
Synonyms	ERR-beta; ERRB2; ERR beta-2; ESRL2; ESRRB; Estrogen-related receptor beta; Estrogen receptor-like 2; NR3B2; Nuclear receptor subfamily 3 group B member 2; Steroid hormone receptor ERR2
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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