NR0B1 Rabbit Polyclonal Antibody

CAT#: TA392552S

DAX1 polyclonal antibody

Size: 25 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 25 ul

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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution WB: 1:1000~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200
Reactivity Human, Pig
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to Human DAX1.
Specificity DAX1 polyclonal antibody detects endogenous levels of DAX1 protein.
Formulation Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration 1mg/ml
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size ~ 48 kDa
Gene Name nuclear receptor subfamily 0 group B member 1
Background DSS-AHC critical region on the X chromosome protein 1 (DAX1) is an orphan nuclear receptor encoded by the nuclear receptor subfamily 0 group B member 1 (NR0B1) gene. DAX1 possesses an atypical DNA binding domain that allows it to form heterodimeric complexes with DNA binding partners and repress transcriptional activity. During development, DAX1 is important for establishment of the hypothalamic-pituitary-adrenal gonadal axis. The receptor is essential for development of several important hormone-producing organs that determine this axis, including the adrenal glands, pituitary, hypothalamus, and the male and female reproductive organs. Research studies suggest that DAX1 plays a role in maintenance of pluripotency in embryonic stem cells. Loss of DAX1 function through deletion or mutation results in adrenal insufficiency and hypogonadotropic hypogonadism, while duplication of the NR0B1 gene on the X-chromosome causes dosage-sensitive sex reversal.
Synonyms DSS-AHC critical region on the X chromosome protein 1; Nuclear receptor DAX-1; Nuclear receptor subfamily 0 group B member 1
Note For research use only, not for use in diagnostic procedure.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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