NF-kB p65 (RELA) Rabbit Polyclonal Antibody

CAT#: TA392530

NFKB-p65 polyclonal antibody

Size: 25 ul 100 ul



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CNY 1,999.00

CNY 3,350.00


货期*
2周

规格
    • 100 ul

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Specifications

Product Data
Applications WB
Recommend Dilution WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200 IF: 1:50~1:200
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to Human NFKB-p65.
Specificity NFKB-p65 polyclonal antibody detects endogenous levels of NFKB-p65 protein.
Formulation PBS with 0.05% proclin300,50% glycerol,pH7.3.
Concentration 1mg/ml
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size ~ 65 kDa
Gene Name RELA proto-oncogene, NF-kB subunit
Background Transcription factors of the nuclear factor κB (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression. NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which translocates to the nucleus.
Synonyms NFKB3; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; RELA; Transcription factor p65
Note For research use only, not for use in diagnostic procedure.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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