GCNF (NR6A1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:2000~1:5000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human NR6A1.
Specificity	NR6A1 polyclonal antibody detects endogenous levels of NR6A1 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 50 kDa
Gene Name	nuclear receptor subfamily 6 group A member 1
Database Link	Entrez Gene 2649 Human UniProt ID Q15406
Background	GCNF (Germ Cell Nuclear Factor), also known as NR6A1 (Nuclear Receptor Subfamily 6 Group A member), is an orphan member of the nuclear receptor gene superfamily. It has been shown to be expressed in the nervous system during development and during specific stages in maturing germ cells of the ovary and testis in the adult, and has probable roles in gametogenesis, neurogenesis, and normal embryonic development during gastrulation. Inactivation of GCNF in mouse results in abnormal posterior development, impaired midbrain development, insufficient closure of the neural tube, and eventual embryonic death. GCNF has been shown to be a repressor of OCT-4 and of the protamine genes and plays a critical role in the control of gene expression during embryogenesis and spermatogenesis.
Synonyms	GCNF; Germ cell nuclear factor; hGCNF; hRTR; NR6A1; Nuclear receptor subfamily 6 group A member 1; Retinoid receptor-related testis-specific receptor; RTR
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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