cIAP1 (BIRC2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:2000~1:5000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human c-IAP1.
Specificity	c-IAP1 polyclonal antibody detects endogenous levels of c-IAP1 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 62 kDa
Gene Name	baculoviral IAP repeat containing 2
Database Link	Entrez Gene 329 Human UniProt ID Q13490
Background	The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain. Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression. In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9. In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase.
Synonyms	Baculoviral IAP repeat-containing protein 2; C-IAP1; Cellular inhibitor of apoptosis; hIAP-2; Hiap2; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; TNFR2-TRAF-signaling complex protein 2
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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