cIAP1 (BIRC2) Rabbit Polyclonal Antibody

CAT#: TA392505S

c-IAP1 polyclonal antibody

Size: 25 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 25 ul

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Specifications

Product Data
Applications WB
Recommend Dilution WB: 1:2000~1:5000
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to Human c-IAP1.
Specificity c-IAP1 polyclonal antibody detects endogenous levels of c-IAP1 protein.
Formulation Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration 1mg/ml
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size ~ 62 kDa
Gene Name baculoviral IAP repeat containing 2
Background The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain. Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression. In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9. In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase.
Synonyms Baculoviral IAP repeat-containing protein 2; C-IAP1; Cellular inhibitor of apoptosis; hIAP-2; Hiap2; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; TNFR2-TRAF-signaling complex protein 2
Note For research use only, not for use in diagnostic procedure.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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