FLT3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:2000~1:5000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human CD135.
Specificity	CD135 polyclonal antibody detects endogenous levels of CD135 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~112 kDa
Gene Name	fms related tyrosine kinase 3
Database Link	Entrez Gene 2322 Human UniProt ID P36888
Background	FMS-related tyrosine kinase 3 (FLT3, also called FLK2), is a member of the Type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system. FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream substrates. The p85 subunit of PI3 kinase, SHP2, GRB2, and Shc have all been reported to associate with FLT3 after FL stimulation. Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regulation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of internal tandem duplications (ITDs) occur in 20% of patients with acute myeloid leukemia.
Synonyms	CD135; EC:2.7.10.1; Fetal liver kinase-2 (FLK-2); FL cytokine receptor; FLT3; Fms-like tyrosine kinase 3 (FLT-3); Receptor-type tyrosine-protein kinase FLT3; Stem cell tyrosine kinase 1 (STK-1)
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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