IL10RA Rabbit Polyclonal Antibody
CAT#: TA392438S
CD210 polyclonal antibody
Size: 100 ul
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CNY 800.00
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CNY 1,430.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1:1000~1:2000 |
Reactivity | Human, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human CD210. |
Specificity | CD210 polyclonal antibody detects endogenous levels of CD210 protein. |
Formulation | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2. |
Concentration | 1mg/ml |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Predicted Protein Size | ~ 80 kDa |
Gene Name | interleukin 10 receptor subunit alpha |
Database Link | |
Background | Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy. |
Synonyms | CDw210a; CD_antigen: CD210; IL-10 receptor subunit alpha; IL-10R1; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL10R; IL10RA; Interleukin-10 receptor subunit 1; Interleukin-10 receptor subunit alpha |
Note | For research use only, not for use in diagnostic procedure. |
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