Biotinylated Anti-CD33 antibody(DM77), Rabbit mAb

CAT#: TA389312

Biotinylated Anti-CD33 antibody(DM77), Rabbit mAb



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CNY 9,230.00


货期*
2周

规格
    • 100 ug

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Specifications

Product Data
Clone Name DM77
Applications ELISA, FC
Recommend Dilution ELISA 1:5000-10000
Flow Cyt 1:100
Reactivity Human
Host Rabbit
Clonality Monoclonal
Formulation 1XPBS
Concentration Lot specific
Purification Purified from cell culture supernatant by affinity chromatography
Conjugation Unconjugated
Storage Condition Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Background Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
Synonyms CD33,SIGLEC3,gp67
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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