EWSR1 Mouse Monoclonal Antibody [Clone ID: 5H7]

Specifications

Product Data
Clone Name	5H7
Applications	ICC, IHC, WB
Recommend Dilution	WB: 1:1000 ICC: 1:1000
Reactivity	Canine, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length recombinant human EWS expressed in and purified from E. coli.
Specificity	Specific for endogenous levels of the ~85 kDa EWS protein.
Formulation	PBS + 50% glycerol and 5 mm NaN3
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Predicted Protein Size	85
Gene Name	EWS RNA binding protein 1
Database Link	Entrez Gene 2130 Human UniProt ID Q01844
Background	The Ewing Sarcoma Breakpoint Region 1 (EWSR1) gene encodes the EWS protein, which along with FUS and TAF15 comprises the FET family of RNA-binding proteins. EWS is primarily expressed in the nucleus, but has also been found in the cytoplasm of secretory cell types (Andersson et al., 2008). Defects of EWSR1 are known to cause Ewing sarcoma and have been implicated in amyotrophic lateral sclerosis (ALS) (Svetoni et al., 2016). Recently, EWS has been shown to directly interact with oncogenic ETS transcription factors in the promotion of prostate cancer (Kedage et al., 2016).
Synonyms	bK984G1.4; EWS
Note	Protein G purified from culture supernatant.
Reference Data

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