EXOSC8 Rabbit Polyclonal Antibody

CAT#: TA388192

EXOSC8 Rabbit polyclonal antibody



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ug

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经常一起买 (1)
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Specifications

Product Data
Applications WB
Recommend Dilution Recommended dilution: WB:1:1000-1:5000
Reactivity Mouse, Human
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant Human Exosome complex component RRP43 protein (2-276AA)
Formulation Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Concentration lot specific
Purification >95%, Protein G purified
Conjugation Unconjugated
Storage Condition Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Background Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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